In silico Identification of SFRP1 as a Hypermethylated Gene in Colorectal Cancers

초록

Aberrant DNA methylation, as an epigenetic marker of cancer, influences tumor development and progression. Wedownloaded publicly available DNA methylation and gene expression datasets of matched cancer and normal pairs from theCancer Genome Atlas Data Portal and performed a systematic computational analysis. This study has three aims to screengenes that show hypermethylation and downregulated patterns in colorectal cancers, to identify differentially methylatedregions in one of these genes, SFRP1, and to test whether the SFRP genes affect survival or not. Our results show that 31hypermethylated genes had a negative correlation with gene expression. Among them, SFRP1 had a differentially methylatedpattern at each methylation site. We also show that SFRP1 may be a potential biomarker for colorectal cancer survival.

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