The Severity of Diabetes and the Risk of Diabetic Foot Amputation: A National Cohort Study

초록

Background: This study aimed to assess whether markers of diabetes severity could serve as predictors for foot amputation riskamong patients with type 2 diabetes mellitus. Methods: We analyzed data from the nationally representative Korean National Health Insurance System database, tracking2,544,077 patients with type 2 diabetes mellitus who participated in routine health check-ups between 2009 and 2012, with followup extending through the end of 2018. The parameters used to define the diabetes severity score encompassed diabetes duration, insulin usage, the number of oral glucose-lowering medications, the presence of chronic kidney disease, diabetic retinopathy, and cardiovascular disease. Each factor was assigned one point, yielding a cumulative severity score ranging from 0 to 6. Results: The risk of diabetic foot amputation was predominantly predicted by insulin therapy, diabetic retinopathy, and a prolongedduration of diabetes. The hazard ratios for foot amputation increased with the severity score as follows: 2.31 (95% confidence interval [CI], 2.15 to 2.47) for a score of 1, 4.73 (95% CI, 4.42 to 5.07) for a score of 2, 8.86 (95% CI, 8.24 to 9.53) for a score of 3, 16.95(95% CI, 15.60 to 18.4) for a score of 4, 23.98 (95% CI, 21.25 to 27.05) for a score of 5, and 37.87 (95% CI, 28.93 to 49.57) for ascore of 6. Conclusion: Specific markers of advanced diabetes effectively identified patients at an elevated risk for diabetic foot amputation.

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