Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Mun, D.-G.; Bhin, J.; Kim, S.; Kim, H.; Jung, J.H.; Jung, Y.; Jang, Y.E.; Park, J.M.; Kim, H.; Jung, Y.; Lee, H.; Bae, J.; Back, S.; Kim, S.; Kim, J.; Park, H.; Li, H.; Hwang, K.-B.; Park, Y.S.; Yook, J.H.; Kim, B.S.; Kwon, S.Y.; Ryu, S.W.; Park, D.; Jeon, T.Y.; Kim, D.H.; Lee, J.-H.; Han, S.-U.; Song, K.S.; Park, D.; Park, J.W.; Rodriguez, H.; Kim, J.; Lee, H.; Kim, K.P.; Yang, E.G.; Kim, H.; Paek, E.; Lee, S.; Lee, S.; Hwang, D.

doi:10.1016/j.ccell.2018.12.003

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Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Mun, D.-G.;
Bhin, J.;
Kim, S.;
Kim, H.;
Jung, J.H.;
... Hwang, K.-B.;
외 35명

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256

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278

초록

We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. © 2018 Elsevier Inc.Mun et al. perform proteogenomic analysis of diffuse gastric cancers (DGC) in a young population, identifying that correlations of mRNA-protein abundance associate with survival and defining four subtypes of DGC. The associations of some subtypes with related pathways are identified mainly by the proteomic data.

키워드

cancer subtypes; correlation between mRNA and protein abundance changes; correlation between mutation and phosphorylation; diffuse gastric cancer; proteogenomics; somatic nonsynonymous mutations

제목: Proteogenomic Characterization of Human Early-Onset Gastric Cancer

저자: Mun, D.-G.; Bhin, J.; Kim, S.; Kim, H.; Jung, J.H.; Jung, Y.; Jang, Y.E.; Park, J.M.; Kim, H.; Jung, Y.; Lee, H.; Bae, J.; Back, S.; Kim, S.; Kim, J.; Park, H.; Li, H.; Hwang, K.-B.; Park, Y.S.; Yook, J.H.; Kim, B.S.; Kwon, S.Y.; Ryu, S.W.; Park, D.; Jeon, T.Y.; Kim, D.H.; Lee, J.-H.; Han, S.-U.; Song, K.S.; Park, D.; Park, J.W.; Rodriguez, H.; Kim, J.; Lee, H.; Kim, K.P.; Yang, E.G.; Kim, H.; Paek, E.; Lee, S.; Lee, S.; Hwang, D.

DOI: 10.1016/j.ccell.2018.12.003

발행일: 2019-01

유형: Article

저널명: Cancer Cell

권: 35

호: 1

페이지: 111 ~ 124.e10

언어: ENG

출판사: Cell Press

발행국가: 미국

ISSN: E 1878-3686
P 1535-6108