유산소성 운동 강도의 차이가 산화적-질소적 스트레스 및 뇌신경세포 생성인자에 미치는 영향

초록

The purpose of the current research is to investigate the effects of different aerobic exercise intensities on neurotrophic factor induced by oxidative–nitrosative stress. The subjects of the current research were 15 healthy male. The subjects were asked to perform treadmill running in three different conditions: 1) low-intensity exercise(LIE, 50%VO2max), 2) moderate-intensity exercise(MIE, 65%VO2max), and 3) high-intensity exercise(HIE, 85%VO2max). Blood sampling were taken at rest, at immediately after- exercise, and at 60minute after-exercise for examining the levels of oxidative–nitrosative stress markers[malonaldehyde(MDA), nitrite, superoxide dismutase(SOD)] and neurotrophic factor[glial cell line-derived neurotrophic factor(GDNF), insulin like growth factor-1 (IGF-1)]. The result of current research shows that the levels of MDA, nitrite, SOD, GDNF and IGF-1 were significantly increased after acute aerobic exercise(p<.05), and the levels of MDA, nitrite, SOD appeared to be significantly higher in HIE compared to LIE and/or MIE(p<.05). These results suggest that acute aerobic exercise can induce increase responses of oxidative–nitrosative stress and neurotrophic factor. It is suggested, however, that high intensity exercise could increase the oxidative-nitrosative stress.

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