The Biological Roles of microRNAs in Drosophila Development

초록

Simple Summary Drosophila (or the fruit fly) is widely used to study developmental processes associated with gene regulation. Insect development, including that of Drosophila, is controlled by various gene regulation mechanisms. In particular, numerous studies on microRNAs (miRNAs) in Drosophila have highlighted their crucial roles in development. This review focuses on the function of miRNAs in various tissues and developmental processes in Drosophila, along with sequencing technologies for studying miRNA interactions with target genes. Abstract Drosophila is a well-established insect model system for studying various physiological phenomena and developmental processes, with a focus on gene regulation. Drosophila development is controlled by programmed regulatory mechanisms specific to individual tissues. When key developmental processes are shared among various insects, the associated regulatory networks are believed to be conserved across insects. Thus, studies of developmental regulation in Drosophila have substantially contributed to our understanding of insect development. Over the past two decades, studies on microRNAs (miRNAs) in Drosophila have revealed their crucial regulatory roles in various developmental processes. This review focuses on the biological roles of miRNAs in specific tissues and processes associated with Drosophila development. Additionally, as a future direction, we discuss sequencing technologies that can analyze the interactions between miRNAs and their target genes, with the aim of enhancing miRNA studies in Drosophila development.

키워드