Effects of Oil type on the Stability of Oil-in-Water Lipid Nanoemulsion

초록

Nanoemulsions are actively used in several applications for pharmaceutical, cosmeticand chemical industries. In this study, we propose the use of microfluidizer known as high pressurehomogenizer to prepare lipid nanoemulsion as a potent cosmetic delivery carrier. The lipidnanoemulsions were prepared by O/W emulsion with hydrogenated lecithin and different type ofoils. Effects of oil type on the stability of the lipid nanoemulsion were investigated with DynamicLight Scattering (DLS) and Zeta-potential. Arbutin was used as model drug for transdermaladministration through hairless mouse skin. Transdermal arbutin delivery using the lipidnanoemulsions was studied with HPLC method.

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