O2-microbubble of iron-porphyrin conjugated polyaspartamide for molecular ultrasound contrast effect

초록

ObjectiveThis study aimed to prepare oxygen-microbubbles incorporating ferrous porphyrin to emulate the oxygen-capturing ability of hemoglobin porphyrin in red blood cells.ResultsWe synthesized poly(2-hydroxyethyl aspartamide) (PHEA) grafted with ferrous porphyrins (Iron-P-PHEA) and created microbubbles using 1,2-dipalmitoyl-sn-glycero-3-phosphocholine. These microbubbles trapped oxygen and retained it over a 2 h period. The O2-microbubbles demonstrated an enhanced photoacoustic effect as an ultrasound contrast agent, as confirmed by Doppler ultrasound testing.ConclusionsThe innovative strategy for O2-microbubble preparation enhances the efficiency of targeted delivery in molecular optical and ultrasound imaging.

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