알킨 말단기를 가진 나선형 폴리이소시아니드의 합성과 MALDI-TOF를 이용한 분석

초록

Block copolymers (BCPs) with rigid structures, such as helical polymers, pose synthetic challenges using traditional polymerization methods. This study presents an approach to synthesizing polyisocyanides (PIs) with alkyne end groups, facilitating the creation of BCPsthrough click chemistry. An aryl nickel complex, modified with a trimethylsilyl-protected alkyne group, was employed as a polymerization catalyst for 4-methoxy isocyanide. The polymerization exhibited high efficiency, producing PIs with controlled molecular weight andnarrow molecular weight distribution. Post-polymerization deprotection reaction yielded alkyne-terminated PIs, enabling the formation of BCPs through copper-catalyzed azide-alkyne cycloaddition click reactions with (R)-3-azido-1-phenylpropal-1-ol and azide-functionalizedpoly(ethylene oxide), successfully forming PI-c-PP and PEO-b-PI block copolymers. Characterization using NMR spectroscopy and MALDI-TOF MS confirmed the successful incorporation and subsequent deprotection of the alkyne groups. This approach provides a versatile route to synthesize end-functionalized helical polymers, enabling the creation of helical-coil block copolymers with potential applications in nanostructure formation.

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