상세 보기
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
- Mahajan, Anubha;
- Go, Min Jin;
- Zhang, Weihua;
- Below, Jennifer E.;
- Gaulton, Kyle J.;
- ... Kim, Sangsoo;
- 외 326명
Citations
WEB OF SCIENCE
831Citations
SCOPUS
883초록
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
키워드
SCALE ASSOCIATION ANALYSIS; TRANSETHNIC METAANALYSIS; GLUCOSE-HOMEOSTASIS; LOCI; VARIANTS; POPULATIONS; MAP; INDIVIDUALS; IMPUTATION; CHROMATIN
- 제목
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
- 저자
- Mahajan, Anubha; Go, Min Jin; Zhang, Weihua; Below, Jennifer E.; Gaulton, Kyle J.; Ferreira, Teresa; Horikoshi, Momoko; Johnson, Andrew D.; Ng, Maggie C. Y.; Prokopenko, Inga; Saleheen, Danish; Wang, Xu; Zeggini, Eleftheria; Abecasis, Goncalo R.; Adair, Linda S.; Almgren, Peter; Atalay, Mustafa; Aung, Tin; Baldassarre, Damiano; Balkau, Beverley; Bao, Yuqian; Barnett, Anthony H.; Barroso, Ines; Basit, Abdul; Been, Latonya F.; Beilby, John; Bell, Graeme I.; Benediktsson, Rafn; Bergman, Richard N.; Boehm, Bernhard O.; Boerwinkle, Eric; Bonnycastle, Lori L.; Burtt, Noel; Cai, Qiuyin; Campbell, Harry; Carey, Jason; Cauchi, Stephane; Caulfield, Mark; Chan, Juliana C. N.; Chang, Li-Ching; Chang, Tien-Jyun; Chang, Yi-Cheng; Charpentier, Guillaume; Chen, Chien-Hsiun; Chen, Han; Chen, Yuan-Tsong; Chia, Kee-Seng; Chidambaram, Manickam; Chines, Peter S.; Cho, Nam H.; Cho, Young Min; Chuang, Lee-Ming; Collins, Francis S.; Cornelis, Marilyn C.; Couper, David J.; Crenshaw, Andrew T.; van Dam, Rob M.; Danesh, John; Das, Debashish; de Faire, Ulf; Dedoussis, George; Deloukas, Panos; Dimas, Antigone S.; Dina, Christian; Doney, Alex S. F.; Donnelly, Peter J.; Dorkhan, Mozhgan; van Duijn, Cornelia; Dupuis, Josee; Edkins, Sarah; Elliott, Paul; Emilsson, Valur; Erbel, Raimund; Eriksson, Johan G.; Escobedo, Jorge; Esko, Tonu; Eury, Elodie; Florez, Jose C.; Fontanillas, Pierre; Forouhi, Nita G.; Forsen, Tom; Fox, Caroline; Fraser, Ross M.; Frayling, Timothy M.; Froguel, Philippe; Frossard, Philippe; Gao, Yutang; Gertow, Karl; Gieger, Christian; Gigante, Bruna; Grallert, Harald; Grant, George B.; Groop, Leif C.; Groves, Christopher J.; Grundberg, Elin; Guiducci, Candace; Hamsten, Anders; Han, Bok-Ghee; Hara, Kazuo; Hassanali, Neelam; Hattersley, Andrew T.; Hayward, Caroline; Hedman, Asa K.; Herder, Christian; Hofman, Albert; Holmen, Oddgeir L.; Hovingh, Kees; Hreidarsson, Astradur B.; Hu, Cheng; Hu, Frank B.; Hui, Jennie; Humphries, Steve E.; Hunt, Sarah E.; Hunter, David J.; Hveem, Kristian; Hydrie, Zafar I.; Ikegami, Hiroshi; Illig, Thomas; Ingelsson, Erik; Islam, Muhammed; Isomaa, Bo; Jackson, Anne U.; Jafar, Tazeen; James, Alan; Jia, Weiping; Joeckel, Karl-Heinz; Jonsson, Anna; Jowett, Jeremy B. M.; Kadowaki, Takashi; Kang, Hyun Min; Kanoni, Stavroula; Kao, Wen Hong L.; Kathiresan, Sekar; Kato, Norihiro; Katulanda, Prasad; Keinanen-Kiukaanniemi, Sirkka M.; Kelly, Ann M.; Khan, Hassan; Khaw, Kay-Tee; Khor, Chiea-Chuen; Kim, Hyung-Lae; Kim, Sangsoo; Kim, Young Jin; Kinnunen, Leena; Klopp, Norman; Kong, Augustine; Korpi-Hyovalti, Eeva; Kowlessur, Sudhir; Kraft, Peter; Kravic, Jasmina; Kristensen, Malene M.; Krithika, S.; Kumar, Ashish; Kumate, Jesus; Kuusisto, Johanna; Kwak, Soo Heon; Laakso, Markku; Lagou, Vasiliki; Lakka, Timo A.; Langenberg, Claudia; Langford, Cordelia; Lawrence, Robert; Leander, Karin; Lee, Jen-Mai; Lee, Nanette R.; Li, Man; Li, Xinzhong; Li, Yun; Liang, Junbin; Liju, Samuel; Lim, Wei-Yen; Lind, Lars; Lindgren, Cecilia M.; Lindholm, Eero; Liu, Ching-Ti; Liu, Jian Jun; Lobbens, Stephane; Long, Jirong; Loos, Ruth J. F.; Lu, Wei; Luan, Jian'an; Lyssenko, Valeriya; Ma, Ronald C. W.; Maeda, Shiro; Maegi, Reedik; Mannisto, Satu; Matthews, David R.; Meigs, James B.; Melander, Olle; Metspalu, Andres; Meyer, Julia; Mirza, Ghazala; Mihailov, Evelin; Moebus, Susanne; Mohan, Viswanathan; Mohlke, Karen L.; Morris, Andrew D.; Muehleisen, Thomas W.; Mueller-Nurasyid, Martina; Musk, Bill; Nakamura, Jiro; Nakashima, Eitaro; Navarro, Pau; Peng-Keat Ng; Nica, Alexandra C.; Nilsson, Peter M.; Njolstad, Inger; Noethen, Markus M.; Ohnaka, Keizo; Ong, Twee Hee; Owen, Katharine R.; Palmer, Colin N. A.; Pankow, James S.; Park, Kyong Soo; Parkin, Melissa; Pechlivanis, Sonali; Pedersen, Nancy L.; Peltonen, Leena; Perry, John R. B.; Peters, Annette; Pinidiyapathirage, Janani M.; Platou, Carl G. P.; Potter, Simon; Price, Jackie F.; Qi, Lu; Radha, Venkatesan; Rallidis, Loukianos; Rasheed, Asif; Rathmann, Wolfgang; Rauramaa, Rainer; Raychaudhuri, Soumya; Rayner, N. William; Rees, Simon D.; Rehnberg, Emil; Ripatti, Samuli; Robertson, Neil; Roden, Michael; Rossin, Elizabeth J.; Rudan, Igor; Rybin, Denis; Saaristo, Timo E.; Salomaa, Veikko; Saltevo, Juha; Samuel, Maria; Sanghera, Dharambir K.; Saramies, Jouko; Scott, James; Scott, Laura J.; Scott, Robert A.; Segre, Ayellet V.; Sehmi, Joban; Sennblad, Bengt; Shah, Nabi; Shah, Sonia; Shera, A. Samad; Shu, Xiao Ou; Shuldiner, Alan R.; Sigurdsson, Gunnar; Sijbrands, Eric; Silveira, Angela; Sim, Xueling; Sivapalaratnam, Suthesh; Small, Kerrin S.; So, Wing Yee; Stancakova, Alena; Stefansson, Kari; Steinbach, Gerald; Steinthorsdottir, Valgerdur; Stirrups, Kathleen; Strawbridge, Rona J.; Stringham, Heather M.; Sun, Qi; Suo, Chen; Syvanen, Ann-Christine; Takayanagi, Ryoichi; Takeuchi, Fumihiko; Tay, Wan Ting; Teslovich, Tanya M.; Thorand, Barbara; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tikkanen, Emmi; Trakalo, Joseph; Tremoli, Elena; Trip, Mieke D.; Tsai, Fuu Jen; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Uitterlinden, Andre G.; Valladares-Salgado, Adan; Vedantam, Sailaja; Veglia, Fabrizio; Voight, Benjamin F.; Wang, Congrong; Wareham, Nicholas J.; Wennauer, Roman; Wickremasinghe, Ananda R.; Wilsgaard, Tom; Wilson, James F.; Wiltshire, Steven; Winckler, Wendy; Wong, Tien Yin; Wood, Andrew R.; Wu, Jer-Yuarn; Wu, Ying; Yamamoto, Ken; Yamauchi, Toshimasa; Yang, Mingyu; Yengo, Loic; Yokota, Mitsuhiro; Young, Robin; Zabaneh, Delilah; Zhang, Fan; Zhang, Rong; Zheng, Wei; Zimmet, Paul Z.; Altshuler, David; Bowden, Donald W.; Cho, Yoon Shin; Cox, Nancy J.; Cruz, Miguel; Hanis, Craig L.; Kooner, Jaspal; Lee, Jong-Young; Seielstad, Mark; Teo, Yik Ying; Boehnke, Michael; Parra, Esteban J.; Chambers, John C.; Tai, E. Shyong; McCarthy, Mark I.; Morris, Andrew P.
- DOI
- 10.1038/ng.2897
- 발행일
- 2014-03
- 유형
- Article
- 저널명
- Nature Genetics
- 권
- 46
- 호
- 3
- 페이지
- 234 ~ +