Dengue Dynamics and Vaccine Cost-Effectiveness Analysis in the Philippines

Shim, Eunha

doi:10.4269/ajtmh.16-0194

상세 보기

Dengue Dynamics and Vaccine Cost-Effectiveness Analysis in the Philippines

Shim, Eunha

Citations

WEB OF SCIENCE

31

Citations

SCOPUS

37

초록

Dengue is one of the most problematic vector-borne diseases in the Philippines, with an estimated 842,867 cases resulting in medical costs of $345 mi l l i o n U . S . d o l l a r s ann u a l l y . I n D ece mb er 2015, t h e f i r s t d e n g u e v a cc in e, k n o w na sc him er i cy e l l o w f e v er v i r u s d e n g u e v i r u s t e t r a v a l e n t d e n g u e v a cc in e, w a s a pp r o v e df or u se in t h e P hi l i pp in es an d i s g i v e n t oc hi l d r e n 9 y e a r so f a g e . T oes t ima t e t h ecos t - e f f ec t i v e n esso f d e n g u e v a cc ina t i o nin t h e P hi l i pp in es, w e d e v e l o p e d ana g e - s t r u c t u r e d m o d e l o f d e n g u e t r an s mi ss i o nan d v a cc ina t i o n . U s in g o u r m o d e l, w eco m p a r e d tw o v a cc ina t i o n sce na r i ose n t ai l in g r o u t in e v a cc ina t i o n p r o g r am s b o t h w i t han d w i t h o u t c a t c h - u p v a cc ina t i o n . O u r r es u l t s in d i c a t e t ha tt h e hi g h er t h ecos t o f v a cc ina t i o n, t h e l esscos t - e f f ec t i v e t h e d e n g u e v a cc ina t i o n p r o g r am . W i t h t h ec u r r e n t d e n g u e v a cc ina t i o n p r o g r am t ha t v a cc ina t esc hi l d r e n 9 y e a r so f a g e, d e n g u e v a cc ina t i o ni scos t - e f f ec t i v e f or v a cc ina t i o n cos t s u pt o$ 70 from a health-care perspective and up to $75 f r o ma soc i e t a l p er s p ec t i v e . U n d er a f a v or ab l esce na r i oco n s i s t in g o f 1 y e a r o f c a t c h - u p v a cc ina t i o n s t ha tt a r g e t c hi l d r e n 9 - 15 y e a r so f a g e, f o l l o w e d b y r e g u l a r v a cc ina t i o n o f 9 - y e a r - o l d c hi l d r e n, v a cc ina t i o ni scos t - e f f ec t i v e a t cos t s u pt o$ 72 from a health-care perspective and up to $78 from a societal perspective. In general, dengue vaccination is expected to reduce the incidence of both dengue fever and dengue hemorrhagic fever/dengue shock syndrome. Our results demonstrate that even at relatively low vaccine efficacies, age-targeted vaccination may still be cost-effective provided the vaccination cost is sufficiently low.

키워드

ANTIBODY-DEPENDENT ENHANCEMENT; SOUTHEAST-ASIA; TRANSMISSION DYNAMICS; SYSTEMATIC ANALYSIS; HEMORRHAGIC-FEVER; DISEASE-MODELS; BURDEN; EPIDEMIOLOGY; THAILAND; BRAZIL

제목: Dengue Dynamics and Vaccine Cost-Effectiveness Analysis in the Philippines

저자: Shim, Eunha

DOI: 10.4269/ajtmh.16-0194

발행일: 2016-11

유형: Article

저널명: American Journal of Tropical Medicine and Hygiene

권: 95

호: 5

페이지: 1137 ~ 1147

언어: ENG

출판사: AMER SOC TROP MED & HYGIENE

발행국가: 미국

분량: 11 페이지

ISSN: E 1476-1645
P 0002-9637